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Ferrostatin-1（鐵抑素-1）

Ferrostatin-1 (Fer-1) 是一種有效的、選擇性的 ferroptosis 抑制劑，抑制 Erastin 誘導(dǎo)的 HT-1080 細(xì)胞鐵死亡 (EC₅₀=60 nM)。Ferrostatin-1 是一種人工合成的抗氧化劑，通過(guò)還原機(jī)制來(lái)防止膜脂的損傷，從而抑制細(xì)胞死亡。具有抗真菌活性。

體外研究(In Vitro)

Ferrostatin-1 (Fer-1) prevents erastin-induced accumulation of cytosolic and lipid ROS. Ferrostatin-1 prevents glutamate-induced neurotoxicity in organotypic rat brain slices^[1].
Fer-1 inhibits lipid peroxidation, but not mitochondrial reactive oxygen species formation or lysosomal membrane permeability

體內(nèi)研究(In Vivo)

Ferrostatin-1 inhibits cell death in cellular models of Huntington's disease (HD), periventricular leukomalacia (PVL), and kidney dysfunction ^[2].
Ferrostatin-1 (0.8?mg/kg; tail vein injection) effectively alleviates LPS-induced induced acute lung injury (ALI)^[4].
Ferrostatin-1 (i.p.; 5 mg/kg; C57BL/6J mice) improves renal function in mice with rhabdomyolysis

分子量：262.35

Formula：C₁₅H₂₂N₂O₂

CAS 號(hào)：347174-05-4

運(yùn)輸條件:Room temperature in continental US; may vary elsewhere.

儲(chǔ)存方式:

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

參考文獻(xiàn):

[1]. Dixon SJ, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012;149(5):1060-1072.

[2]. Skouta R, Dixon SJ, Wang J, et al. Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models. J Am Chem Soc. 2014;136(12):4551-4556.

[3]. Horwath MC, et al. Antifungal Activity of the Lipophilic Antioxidant Ferrostatin-1. Chembiochem. 2017;18(20):2069-2078.

[4]. Liu P, Feng Y, et al. Ferrostatin-1 alleviates lipopolysaccharide-induced acute lung injury via inhibiting ferroptosis. Cell Mol Biol Lett. 2020;25:10. Published 2020 Feb 27.

[5]. Melania Guerrero Hue, et al. FP282 FERROPTOSIS-MEDIATED CELL DEATH IS DECREASED BY CURCUMIN IN RENAL DAMAGE ASSOCIATED TO RHABDOMYOLYSIS, Nephrology Dialysis Transplantation, Volume 34, Issue Supplement_1, June 2019, gfz106.FP282.